- Primate pancreas: antibodies against islet cells.
- Detection of antibodies against islet cells.
- Indications: Differentiation between a late manifestation of diabetes type 1 (latent autoimmune diabetes in adulthood, LADA) and diabetes type 2.
- For a reliable determination of antibodies against islet cells an extended incubation time of 18 hours for the patient serum must be observed. The incubation time may be reduced to 2 hours but this will lead to a decrease in the sensitivity of the antibody detection test.
- Standardised control with JDF units available (order no. CA 1021-0101-1).
- With indirect immunofluorescence autoantibodies against pancreas islets (ICA) can be detected in 80% of patients with new-onset diabetes type 1. Two target antigens of ICA have been identified so far: the enzymes glutamic acid decarboxylase (GAD) and tyrosine phosphatase (IA2).
- This BIOCHIP may be supplemented with further substrates, e. g. primate cerebellum for the detection of antibodies against GAD.
- The microscopic evaluation can be significantly simplified by using small BIOCHIPs (1 x 1 mm). The BIOCHIPs appear almost completely in the field of view and facilitate finding the islet cells, thus rendering a time-consuming search unnecessary, especially in negative samples.
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