Antibodies against Emerging Viruses
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Indirect Immunofluorescence Test
- Over the past years it has been observed that a number of new viruses ("emerging viruses") and other pathogens has spread worldwide, introducing since then unknown diseases into previously unaffected regions.
- EUROIMMUN offers a broad spectrum of indirect immunofluorescence tests for the detection of specific antibodies (see table).
- Many of these substrates are available as single substrate with non-infected cells or as useful combinations (syndrome or geographically orientated) for the investigation of serum samples.
- IgG absorption as preparatory step for the determination of specific antibodies of class IgM: page 58.
- Cross reactions within the virus family, especially with Flaviviruses, should be taken into consideration since they may cause false-positive results. The infectious agent can be determined by titration of the sample and comparison of titers.
| Pathogen | Disease, syndromes |
Corona virus: | ||
SARS corona virus (SARS-CoV) | Severe acute respiratory syndrome (SARS) | |
Flaviviruses: | ||
TBE virus (TBEV) | Tick-borne encephalitis | |
West Nile virus (WNV) | West Nile fever, encephalitis | |
Japanese encephalitis virus (JEV) | Japanese encephalitis | |
Yellow fever virus (YFV) | Yellow fever, hepatitis, haemorrhagic fever, arthritis | |
Dengue virus (DENV, types 1-4) | Dengue fever, haemorrhagic fever | |
Bunyaviruses: | ||
Hantavirus (types Hantaan, Puumala, Seoul, Saaremaa, Dobrava, and Sin Nombre) | HFRS (haemorrhagic fever with renal syndrome); HCPS (Hantaviral cardiopulmonary syndrome) | |
Sandfly fever virus (types Sicilian, Naples, Toscana and Cyprus) | Pappataci fever, meningitis, encephalitis | |
Rift valley fever virus (RVFV) | Rift valley fever, haemorrhagic fever, hepatitis | |
Crimean-Congo fever virus (CCHFV-GPC and -N) | Crimean-Congo haemorrhagic fever | |
Togaviruses: | ||
Chikungunya virus (CHIKV) | Chikungunya fever, arthritis | |
Kinetoplastida: | ||
Leishmania donovani | Visceral leishmaniasis | |
Haemosporina: | ||
Plasmodium falciparum | Malaria tropica | |
Plasmodium vivax | Malaria tertiana |
Microplate ELISA: Anti-TBE Virus, Anti-West Nile Virus, Anti-Dengue Virus
- Incubated ELISA Anti-TBE virus, Anti-WNV, Anti-Dengue virus.
- Monospecific determination of antibodies against TBE, West Nile and Dengue virus.
- Serum dilution 1: 100, conjugate class anti-human IgG or IgM, POD-labelled.
- 1-point calibration, semiquantitative (IgM) or 3-point calibration, quantitative (IgG). Similar incubation conditions and times: All tests can be combined on one and the same microplate.
- IgM test kit with IgG/RF absorbent in the sample buffer for IgG absorption as preparatory step for the determination of specific IgM antibodies.
- Available single ELISA:
Antigen | Order No. | |
TBE |
| EI 2661-9601 G or M, avidity, Ab determination in CSF |
TBE "Vienna" | EI 2661-9601-9 G | |
WNV | EI 2662-9601 G or M, avidity | |
Dengue | EI 266b-9601 G or M |
